Decrease in the activity of the L-type Ca-channels and its reversal by NF-κB inhibitors in colonic smooth muscle isolated from a TNBS-induced colitis model rat
نویسندگان
چکیده
We investigated the mechanisms of dysmotility of the colonic circular muscle of the Crohn’s disease model rat. Contractions induced by KCl, carbachol, and Bay K 8644 were decreased in circular smooth muscles isolated from TNBS-induced colitis rat colon. However, the absolute force and Ca sensitivity of contractile proteins were not affected as assessed in α-toxin permeabilized smooth muscle. The current density of the L-type Ca-channel in circular smooth Copyright (c) 2003 by the American Physiological Society. Articles in PresS. Am J Physiol Gastrointest Liver Physiol (March 19, 2003).10.1152/ajpgi.00038.2003
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